General Manager – Pharmaceutical Manufacturing General Manager – Pharmaceutical Manufacturing
Position Type: Permanent
Context We are supporting a pharmaceutical manufacturing organization based in Toronto that operates in a highly regulated GMP environment and is part of a Private Equity portfolio. The company is in a phase of performance optimization, value creation, and long-term scalability under PE ownership.
The organization is seeking a top-tier General Manager to lead site operations and play a critical role in executing the PE value-creation plan. This role requires a rare combination of senior executive leadership, deep technical expertise in pharmaceutical manufacturing, and strong people leadership.
The General Manager will have full accountability for site operations and will work closely with ownership and senior stakeholders to deliver sustainable operational performance, compliance, and growth.
Key Responsibilities Provide overall leadership and strategic direction for the pharmaceutical manufacturing site
Hold full P&L; and operational accountability for the site
Lead all site functions including Manufacturing, Quality Assurance, Quality Control, Supply Chain, Engineering, Maintenance, EHS, and HR
Ensure sustained compliance with GMP, Health Canada, FDA, and applicable regulatory standards
Establish and reinforce a solid quality culture with rigorous documentation, right-first-time execution, and inspection readiness




Drive continuous improvement across safety, quality, service level, productivity, and cost in line with PE value-creation objectives
Execute operational improvement initiatives to enhance EBITDA, cash flow, and operational scalability
Lead site strategy, capacity planning, and capital investment decisions
Build, develop, and retain a high-performing leadership team
Act as the primary interface with corporate leadership, Private Equity owners, and regulatory authorities
Lead and support regulatory inspections, audits, and remediation activities as required
Profile Senior pharmaceutical executive with experience as a General Manager, Site Head, Plant Director, or equivalent
Minimum 15 years of experience in pharmaceutical or life sciences manufacturing environments
Strong technical background with deep knowledge of GMP operations, quality systems, and regulatory compliance
Demonstrated experience operating in Private Equity–backed or high-accountability environments
Proven track record of driving performance improvement, value creation, and operational excellence
Highly credible leader with strong presence on the shop floor and in executive settings
Excellent people leadership, communication, and change management skills
Strategic yet hands-on, with a strong execution mindset
Experience interacting with Health Canada, FDA, and global regulatory bodies

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📌 General Manager – Pharmaceutical Manufacturing (Ontario)
🏢 xNorth
📍 Ontario