Pouladi Laboratory Department of Medical Genetics Faculty of Medicine (Mahmoud Pouladi)
Job End Date
March 31 2028
Posting End Date
December 12 2026
Note: Applications will be accepted until 11:59 PM on the Posting End Date.
The expected pay (or pay range) for this position is between $76128 - $90000 per annum.
At UBC we believe that attracting and sustaining a diverse workforce is key to the successful pursuit of excellence in research innovation and learning for all faculty staff and students. Our commitment to employment equity helps achieve inclusion and fairness brings rich diversity to UBC as a workplace and creates the necessary conditions for a rewarding career.
The UBC Department of Medical Genetics seeks to be an inspiring andproductive community of scholars; an outstanding provider of knowledgetechnical expertise and compassionate care for our patients;contributors to the scientific advance of our discipline; and a credible and respected source of information and advice to society atlarge. While focusing on areas of genetic medicine that we deem to beparticularly important we view diversity of approach and techniques tobe an essential strength of our Department.
We acknowledge that the University of British Columbia Faculty of Medicine and its distributed programs which include four university academic campuses are located on traditional ancestral and unceded territories of Indigenous peoples around the province.
The Department of Medical Genetics at The University of British Columbia (UBC) invites applications for a fixed-term full-time Research Associate.
Reporting to Dr. Mahmoud Pouladi the successful candidate will hold an MD/PhD in Anatomy Histology or Pathology with a focus on neurobiology and 5 years of postdoctoral experience and have:
- At least 10 years experience in laboratory research involving mouse models.
- Expertise in histology such as immunofluorescence staining immunohistochemistry in situ hybridisation (ISH) labelling transmission electron microscopy (TEM) Golgi staining dye tracing for anatomical brain connectivity mapping whole brain 3D structure staining clearing and imaging.
- Animal husbandry and related skills such as weaning tailing mouse behaviour testing perfusions tissue microdissection in vivo delivery in the nervous system in utero electroporation and stereotaxic injections.
- Expertise in molecular biology techniques such as Western blotting PCR quantitative PCR molecular cloning Co-IP and ChIP/CLIP.
- Expertise with ex vivo / in vitro cell culture techniques such as organotypic brain slice culture brain tissue transplantation primary cell culture cell line culture transfections and lentivirus infection.
- Experience working with human pluripotent stem cells and their neural differentiation.
- Experience using genome editing using CRISPR/Cas9 in immortalized and human pluripotent stem cell lines.
Responsibilities include:
- Development and analysis of novel mouse and human pluripotent stem cell models of genetic neurological disorders.
- Analysis of brain development defects in mouse models of genetic disorders.
- Preclinical therapeutic studies in human pluripotent stem cell and mouse disease models.
- Performing and/or supervising behavioral and histological analyses of novel mouse models of genetic neurological disorders to elucidate the pathophysiology behind the disease including managing mouse lines and carrying out relevant procedures such as behavioural experiments microinjection tissue collection various types of sectioning and staining.
- Differentiation of human pluripotent stem cells into neural cell types and organoids.
- Maintenance expansion and analysis of cell line brain slice and primary neuron cultures.
- Perform CRISPR-Cas9 genome editing lentivirus infection shRNA and transfection to knockout knockdown or overexpress to regulate gene expression levels.
- Electrophysiological recording such as multi-electrode array (MEA)
A full job description can be requested at .
An application package should include a letter of application outlining the applicants research interests and experience accompanied by a detailed curriculum vitae and the names of three referees.
The University of British Columbia is a global centre for research and teaching consistently ranked among the top 20 public universities in the world. Since 1915 UBCs entrepreneurial spirit has embraced innovation and challenged the status quo. UBC encourages its students staff and faculty to challenge convention lead discovery and explore new ways of learning. At UBC bold thinking is given a place to develop into ideas that can change the world.
Our Vision: To Transform Health for Everyone.
Ranked among the worlds top medical schools with the fifth-largest MD enrollment in North America the UBC Faculty of Medicine is a leader in both the science and the practice of medicine. Across British Columbia more than 12000 faculty and staff are training the next generation of doctors and health care professionals making remarkable discoveries and helping to create the pathways to better health for our communities at home and around the world.
The Faculty - comprised of approximately 2200 administrative support technical/research and management and professional staff as well approximately 650 full time academic and over 10000 clinical faculty members - is composed of 19 academic basic science and/or clinical departments three schools and 24 research centres and institutes. Together with its University and Health Authority partners the Faculty delivers innovative programs and conducts research in the areas of health and life sciences. Faculty staff and trainees are located at university campuses clinical academic campuses in hospital settings and other regionally based centres across the province.
Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code including sex sexual orientation gender identity or expression racialization disability political belief religion marital or family status age and/or status as a First Nation Metis Inuit or Indigenous person. All qualified candidates are encouraged to apply; however Canadians and permanent residents of Canada will be given priority.
Required Experience:
IC
📌 Research Associate Pouladi Lab (Vancouver)
🏢 University of British Columbia
📍 Vancouver
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