KisoJi Biotech is advancing next-generation antibody therapeutics through the integration of proprietary transgenic heavy chain-only antibody (HCAb) platforms, AI-guided discovery, functional screening technologies, and high-throughput single-cell screening systems.

We are currently expanding our antibody discovery capabilities and are seeking two Senior Research Associates to lead and support our single B cell screening and functional antibody discovery workflows using advanced technologies including the CellCelector platform and potentially droplet microfluidics-based screening systems.

This is a highly hands-on laboratory role focused on screening plasma B cells following immunization campaigns to identify antibodies with desirable binding and/or functional activity. The position will involve close collaboration with multidisciplinary teams spanning molecular biology, protein engineering, AI-guided discovery, and functional assay development.

The successful candidates will thrive in a fast-paced biotech environment, demonstrate strong experimental rigor, work independently, and contribute scientifically to the development of next-generation antibody discovery technologies.

Position

Senior Research Associate

Department

Assay Development

Responsibilities

- Plan and execute single B cell and plasma cell screening workflows following animal immunization campaigns
- Operate and optimize the CellCelector platform for single-cell isolation, imaging, clone recovery, and antibody discovery applications
- Develop and execute screening assays for:
- Cell-based functional activity




- Support the implementation and optimization of droplet microfluidics-based screening technologies for high-throughput functional antibody discovery
- Perform mammalian cell culture and support functional screening workflows using reporter assays, flow cytometry, imaging systems, and cell-based assays
- Troubleshoot methods, improve workflows, and contribute to the development of current antibody discovery technologies
- Maintain accurate experimental records and clearly communicate results through reports, presentations, and team discussions
- Assist in SOP development, workflow standardization, and laboratory organization
- Collaborate closely with multidisciplinary teams across discovery, assay development, computational biology, and protein engineering
- Participate in project planning, prioritization, and technology evaluation discussions

Essential Qualifications

- M.Sc. in Immunology, Cell Biology, Molecular Biology, Biotechnology, Bioengineering, or a related field with at least 5–7 years of industry experience
- Minimum 3 years of hands-on experience in antibody discovery or single-cell screening workflows
- Experience with mammalian cell culture and cell-based functional assays
- Experience operating advanced screening or cell handling instrumentation such as:
- CellCelector
- FACS / flow cytometry systems
- Experience with one or more of the following:




- Single B cell screening
- Functional antibody screening
- Reporter-based functional assays
- Strong troubleshooting and problem-solving skills with the ability to independently optimize assays and workflows
- Excellent organizational skills and attention to detail
- Ability to work independently while effectively collaborating within cross-functional teams
- Strong verbal and written communication skills
- Legally authorized to work in Canada

Assets

- Experience with droplet microfluidics systems for single-cell or functional screening
- Experience with flow cytometry assay development and cell sorting
- Experience with reporter assays, imaging-based screening, or phenotypic screening
- Familiarity with automation and high-throughput screening systems
- Experience in oncology or GPCR-focused therapeutic discovery programs

What We Offer

Benefits Package Includes

- Health and Dental Insurance Plans
- Paid Vacation and Holidays

Incentive Programs Include

- Training & Development Programs / Courses
- Annual Performance Reviews with Yearly Bonuses
- Opportunity to work with cutting-edge antibody discovery technologies
- Exposure to advanced AI-guided therapeutic discovery platforms

The salary range for this position is $80,000–120,000 CAD, depending on experience, technical expertise, and qualifications. Compensation will take into account internal equity, work location, and relevant industry experience.

KisoJi Biotech is a collaborative and science-driven organization where innovation, teamwork, and scientific rigor are highly valued. Together, we believe we can

📌 Senior Research Associate – Single B Cell Screening (Toronto)
🏢 Kisoji Biotechnology
📍 Toronto