Academic Job Category Faculty Non Bargaining Job Title Postdoctoral Research Fellow – Human Neuroimmunology, Brain Organoids and Multi-omics Department MS Research Network | Department of Medicine | Faculty of Medicine (Jan Lunemann) Posting End Date September 26, 2026 Note: Applications will be accepted until 11:59 PM on the Posting End Date. Job End Date September 30, 2028 Please note: This is a 2-year term appointment with the possibility of extension The expected pay range for this position is CAD $65,000–75,000 per annum plus advantages. The Department of Medicine, Faculty of Medicine is committed to offering equitable and competitive salaries, commensurate with the qualifications and experience of the candidate. At UBC, we believe that attracting and sustaining a diverse workforce is key to the successful pursuit of excellence in research, innovation, and learning for all faculty, staff and students. Our commitment to employment equity helps achieve inclusion and fairness, brings rich diversity to UBC as a workplace, and creates the necessary conditions for a rewarding career.

Job Summary The Laboratory of Professor Jan D. Lünemann, UBC Chair in Multiple Sclerosis and Autoimmune Neurology Research, invites applications for a highly motivated and intellectually curious Postdoctoral Fellow to join an interdisciplinary research program at the Djavad Mowafaghian Centre for Brain Health (DMCBH), one of Canada's leading neuroscience research centres.

The successful candidate will develop next‑generation human experimental models to investigate the cellular and molecular mechanisms underlying autoimmune and inflammatory diseases of the central nervous system, including multiple sclerosis, neuromyelitis optica spectrum disorders (NMOSD), MOG antibody‑associated disease (MOGAD),



autoimmune encephalitis, and related neurological disorders. The project combines human induced pluripotent stem cell (hiPSC) technology, brain organoids, genome engineering, advanced imaging, systems immunology, and high‑throughput multi‑omics to investigate neuroimmune interactions and identify novel therapeutic targets.

The successful candidate will join a rapidly expanding international research program dedicated to uncovering the mechanisms of immune‑mediated diseases of the nervous system through human discovery science. Embedded within an extensive interdisciplinary network of experts in neuroimmunology, stem cell biology, biomedical engineering, computational biology, artificial intelligence, and precision medicine across UBC, they will have access to cutting‑edge research infrastructure, including human stem cell and organoid platforms, genome engineering technologies, advanced microscopy, spectral flow cytometry, single‑cell and spatial genomics, proteomics and biomarker laboratories, and high‑performance computational resources.

The laboratory is deeply committed to excellent mentorship and fostering the professional development of early‑career researchers through extensive national and international collaborations.

Organizational Status





The Postdoctoral Research Fellow will report directly to Professor Lünemann and collaborate closely with investigators across the Faculty of Medicine, DMCBH, the School of Biomedical Engineering, the Life Sciences Institute, and national and international collaborators. Professor Lünemann is the inaugural UBC Chair in Multiple Sclerosis and Autoimmune Neurology Research and Director of the UBC MS & Neuromyelitis Optica Programme. His laboratory combines human discovery science with advanced experimental technologies to understand disease mechanisms and develop precision therapeutics for autoimmune neurological diseases.

Work Performed

- Design and lead innovative research projects investigating mechanisms of neuroinflammation and neurodegeneration.
- Generate and characterize human brain organoids and neural assembloids derived from human induced pluripotent stem cells (hiPSCs).
- Differentiate hiPSCs into neural cell populations including neurons, astrocytes, oligodendrocytes, and microglia.
- Develop complex neuroimmune co‑culture systems incorporating immune cells into human CNS models.
- Apply CRISPR/Cas‑based genome engineering technologies to investigate disease‑associated genes and signalling pathways.
- Perform functional immunological experiments investigating immune‑cell activation, cytokine responses, antibody‑mediated mechanisms, complement activation, and neuroimmune communication.
- Apply advanced microscopy techniques including confocal microscopy, live‑cell imaging, high‑content imaging, and three‑dimensional image analysis.
- Perform and integrate high‑dimensional molecular analyses, including single‑cell RNA sequencing, spatial transcriptomics, proteomics, immune repertoire sequencing, and other multi‑omics technologies.
- Collaborate with computational

📌 Postdoctoral Research Fellow – Human Neuroimmunology, Brain Organoids and Multi-omics (Vancouver)
🏢 University of British Columbia
📍 Vancouver