Montreal Heart Institute, Faculty of Medicine, University of Montreal

The Cardiac Regulatory Genomics Lab at the Montreal Heart Institute is recruiting a postdoctoral fellow in bioinformatics. We investigate how noncoding DNA, long noncoding RNAs and three-dimensional chromatin architecture regulate cardiovascular development, function and disease.

The fellow will integrate computational genomics with experimental studies to identify and characterize cardiac regulatory mechanisms. Research directions include enhancer–gene interactions, noncoding RNA function and the functional interpretation of genetic variants associated with cardiovascular disease, including hypertrophic cardiomyopathy.

Key Responsibilities

- Analyze and integrate transcriptomic, epigenomic and chromatin interaction datasets, including single-cell or single-nucleus data.
- Develop reproducible analysis workflows and prioritize candidate regulatory elements,



RNAs and disease-associated variants for experimental validation.
- Work closely with experimental researchers, contribute to manuscripts and grant proposals, and support trainee development.

Candidate profile

- PhD completed or nearing completion in bioinformatics, computational biology, genomics or a related discipline.
- Robust programming skills in R and/or Python, experience with Linux and statistical analysis, and demonstrated ability to analyze high-throughput sequencing data.
- Experience in regulatory genomics, multiomics integration or single-cell analysis is an asset; interest in cardiovascular biology and collaborative research is essential.

We welcome applications from candidates with diverse backgrounds and perspectives.

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📌 Postdoctoral Researcher (Montreal)
🏢 Santé Québec - Institut de cardiologie de Montréal
📍 Montreal