Job Title Postdoctoral Research Fellow - DNA/Aptamer Chemist
Employment Category Academic
Job Category Faculty Non Bargaining
Department Research | Perrin Lab | Department of Chemistry | Faculty of Science (David Perrin)
Posting End Date October 23, 2026
Note Applications will be accepted until 11:59 PM on the Posting End Date.
Job End Date October 31, 2027
Salary The expected pay range for this position is $55,000 - $65,000/annually.
Location The primary work location is the UBC Vancouver Campus
Employment Type Seeking full-time PDF for 12 months with possibility of extension.
Responsibilities Design and synthesis of DNA aptamers and modified oligonucleotides.
Solid-phase oligonucleotide synthesis, purification and quality control.
Chemical modification and functionalization of DNA, including incorporation of linkers, fluorophores, chelators and other functional groups.
Purification and analytical characterization using HPLC, LC-MS and related approaches.
Systematic structure-function studies using nucleotide substitutions, truncations and chemical modifications.
Development of aptamers with improved affinity, selectivity and stability.
Quantitative characterization of aptamer-protein interactions using biochemical and biophysical approaches.
Conjugation of aptamers to imaging or therapeutic payloads.
Collaboration with protein biochemists, molecular biologists, structural biologists and imaging scientists.
Qualifications Candidates should have a PhD in chemistry, chemical biology, biochemistry or a closely related field. Candidates must have demonstrated experience i.e.



published work in several of the following areas:
Oligonucleotide/DNA chemistry
Solid-phase oligonucleotide synthesis
Nucleic acid modification and conjugation
Aptamer development or SELEX
Protein-ligand binding assays
Bioanalytic skill including techniques such as SPR, BLI, MST, ITC, HPLC and LC-MS
Structure-function analysis of nucleic acids
Nucleic acid-protein interactions
Optional Additional Experience Experience with radiochemistry, chelator chemistry, structural biology or therapeutic oligonucleotide development would be an asset but is not required.
Job Overview We are looking for someone with solid experimental skills who can independently design and troubleshoot experiments, develop new chemical and biochemical approaches, and work effectively within a collaborative multidisciplinary research environment.
Application Deadline Applications will be reviewed so long as the job posting is live.
Equity and Diversity Statement UBC hires on the basis of merit and is committed to employment equity. Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged.



Inclusion is built by individual and institutional responsibility through continuous engagement with diversity to inspire people, ideas, and actions for a better world. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Métis, Inuk, or Indigenous person. UBC acknowledges that certain circumstances may cause career interruptions that legitimately affect an applicant’s record of research or educational leadership achievement. We encourage applicants to note in their applications whether they would like consideration given to the impact of any circumstances, such as those due to health or family reasons, in order to allow for a fair assessment of their research productivity.
All qualified candidates are encouraged to apply; however Canadian citizens and permanent residents will be given priority, and members of historically marginalized groups will be given special consideration.
If you have any needs or questions regarding accommodations or accessibility during the job application, recruitment and hiring process or for more information and support, please visit UBC’s Center For Workplace Accessibility website at https://hr.ubc.ca/health-and-wellbeing/working-injury-illness-ordisability/centre-workplace-accessibility or contact the Centre at [email protected].

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📌 Postdoctoral Research Fellow - DNA/Aptamer Chemist (British Columbia)
🏢 The University of British Columbia
📍 British Columbia