Position Summary

North York Research Inc. (NYRI) is the clinical research division of North York Dermatology Clinic. We conduct multiple concurrent Phase II–IV industry-sponsored clinical trials, with a strong focus on dermatology.

We are seeking an experienced Registered Nurse with direct clinical trial experience to join our research team as a Clinical Research Nurse / Clinical Research Coordinator.

This is a hands-on, patient-facing clinical research position combining nursing responsibilities with clinical trial coordination. The successful candidate will participate directly in the screening, treatment, monitoring, and follow-up of clinical trial participants while coordinating study activities in accordance with study protocols, Good Clinical Practice, and site procedures.

We are specifically looking for an RN who already has practical experience working with human participants in clinical trials. This position is not intended as an entry-level introduction to clinical research.

The ideal candidate will combine strong nursing judgment with clinical research experience, excellent documentation skills, attention to detail, and the ability to independently manage assigned study responsibilities.

Dermatology clinical trial experience is highly desirable.

Work Schedule

This is a full-time, on-site position at our North York location.

Core hours are 8:00 AM to 5:00 PM, Monday through Friday. Reliable attendance and the ability to consistently start work at 8:00 AM are required.

Occasional flexibility within clinic hours may be required based on participant visits, dosing schedules, laboratory processing requirements, or other protocol-related activities.

Key Responsibilities

Clinical Care and Participant Safety

- Perform nursing assessments, obtain vital signs, and review medical histories, concomitant medications, and changes in participant health
- Perform phlebotomy and other assigned study procedures within professional scope and documented training
- Prepare and administer study medications, including subcutaneous injections, according to protocol requirements, authorized orders, and assigned responsibilities
- Complete required dosing checks, injection-site documentation, and post-dose observations
- Identify, document, and promptly escalate adverse events, abnormal findings, and participant concerns
- Support AE/SAE follow-up and safety reporting in collaboration with investigators and the research team
- Respond appropriately to clinical concerns and emergencies within nursing scope and site procedures
- Educate participants regarding study medications, self-administration where applicable, dosing diaries, visit requirements, and when to contact the study team
- Maintain participant safety as the highest priority throughout study participation

Clinical Trial Coordination

- Coordinate assigned clinical trials and participant visits according to protocol requirements
- Participate directly in participant identification, recruitment, pre-screening, screening, and informed consent
- Coordinate study visits with investigators and research staff and ensure required procedures and assessments are completed within protocol windows
- Maintain regular participant communication and follow-up to support attendance, adherence, and retention
- Support dermatology assessments, clinical photography, participant questionnaires, and other protocol-specific procedures according to training and delegation
- Collect, label, process, store, and coordinate shipment of biological specimens according to study laboratory manuals
- Maintain study blinding and comply with role-specific access restrictions where assigned to blinded or unblinded activities
- Serve as a point of contact for assigned study participants




- Communicate directly and professionally with investigators, sponsors, CROs, monitors, and other study personnel as required
- Take ownership of assigned study responsibilities and follow outstanding issues through to resolution

Documentation and Study Quality

- Complete accurate, timely, and contemporaneous source documentation
- Enter and review data in Electronic Data Capture (EDC) systems and resolve assigned data queries
- Maintain medication administration records, specimen logs, and assigned investigational product accountability records
- Support regulatory documentation and maintenance of complete, inspection-ready study files
- Maintain accurate clinical and laboratory documentation, including required logs and study records
- Support clinical supply readiness, equipment checks, and temperature monitoring
- Prepare for and participate in sponsor/CRO monitoring visits
- Assist with audit and regulatory inspection preparation when required
- Identify, document, and appropriately escalate protocol deviations
- Participate in corrective and preventive actions when applicable
- Conduct assigned activities in accordance with approved protocols, ICH-GCP, applicable regulatory requirements, professional nursing standards, and site SOPs

Required Qualifications

Applicants must have

- Current registration as a Registered Nurse (RN) in good standing with the College of Nurses of Ontario
- Current Basic Life Support certification
- Direct, hands-on experience working with human participants in clinical trials
- Experience working at an investigative research site or in a comparable patient-facing clinical trial environment
- Experience with participant screening, informed consent, protocol-driven study visits, source documentation, and EDC
- Demonstrated competence in nursing assessment
- Phlebotomy experience
- Experience administering subcutaneous medications
- Strong understanding of participant safety and appropriate escalation of clinical concerns
- Ability to recognize and appropriately document adverse events and changes in participant condition
- Strong documentation skills and ability to follow detailed study protocols and procedural instructions
- Strong organizational and time-management skills
- Professional written and verbal communication skills
- Ability to manage multiple priorities and time-sensitive study activities
- Ability to work independently within assigned responsibilities while collaborating effectively with investigators and the research team
- Proficiency with electronic documentation and Microsoft Office
- Ability to work full-time in office and reliably start at 8:00 AM

Preferred Qualifications

- 2 or more years of direct site-level clinical trial experience
- Previous Clinical Research Nurse or Clinical Research Coordinator experience
- Experience independently coordinating industry-sponsored Phase II–IV clinical trials
- Dermatology clinical research experience
- Experience with investigational medications and participant safety follow-up
- Experience with AE/SAE documentation and reporting
- Experience preparing for and participating in sponsor/CRO monitoring visits
- Experience with investigational product accountability
- Familiarity with EDC, CTMS, ePRO/eDiary, IRT/IWRS, and laboratory portals
- Experience with study start-up, regulatory documentation, and close-out
- Training in ICH-GCP, TCPS 2, and Health Canada Division 5




- Biological specimen transportation training
- Experience with dermatology outcome assessments or standardized clinical photography
- ACRP or SOCRA clinical research certification

Candidate Fit This position is best suited to an RN who:

- Has already worked directly with clinical trial participants
- Wants to combine nursing practice with hands-on clinical trial coordination
- Is comfortable taking ownership of assigned study responsibilities
- Places participant safety and data integrity first
- Is highly organized and attentive to detail
- Can follow complex protocols accurately
- Recognizes problems early and escalates appropriately rather than guessing or improvising
- Communicates confidently with participants, investigators, sponsors, CROs, and monitors
- Is comfortable working in a fast-paced environment with multiple concurrent clinical trials
- Is interested in building a long-term career in clinical research
- Is comfortable remaining actively involved in day-to-day participant care and clinical trial operations

Working at NYRI This position offers an experienced research nurse the opportunity to combine direct participant care with meaningful clinical trial coordination in a specialized dermatology research environment.

NYRI conducts multiple concurrent industry-sponsored studies and works closely with North York Dermatology Clinic, providing exposure to a broad range of dermatologic diseases, study protocols, investigational therapies, sponsors, and CROs.

The successful candidate will work closely with investigators, Clinical Research Coordinators, Research Assistants, and research management and will have the opportunity to take on increasing responsibility based on demonstrated competence, experience, and performance.

Application Instructions

Please apply with your resume only.

Your resume should clearly identify your clinical trial experience, including your direct involvement with study participants and any experience with participant recruitment, informed consent, study visits, investigational medications, EDC, safety documentation, monitoring visits, or independent study coordination.

This position requires current RN registration in Ontario and previous hands-on clinical trial experience.

Expected hours: 40.0 per week

Application question(s)

- Q1. Are you currently registered as a Registered Nurse (RN) in good standing with the College of Nurses of Ontario?

☐ Yes ☐ No
- Q2. How much direct, hands-on experience do you have working with human participants in clinical trials?

☐ No direct clinical trial experience ☐ Less than 1 year

☐ 1–2 years

☐ 2–5 years

☐ More than 5 years

- Q3. Have you personally performed ALL or MOST of the following as part of a clinical trial: participant screening, informed consent, protocol-driven study visits, source documentation, and EDC data entry?

☐ Yes ☐ No
- Q4. Have you personally coordinated or had substantial responsibility for an industry-sponsored interventional clinical trial at an investigative research site?

☐ Yes ☐ No
- Q5. Which of the following have you personally performed in a clinical trial setting? Select all that apply.

☐ Phlebotomy ☐ Subcutaneous medication administration

☐ Participant recruitment and screening

☐ Informed consent

☐ AE/SAE documentation or safety follow-up

☐ EDC data entry and query resolution

☐ Investigational product accountability

☐ Sponsor/CRO monitoring visits

☐ Biological sample processing and shipment

☐ None of the above

- Q6. This is a full-time, fully on-site position in North York, Toronto, Monday through Friday, and requires reliable attendance with an 8:00 AM start. Can you consistently work this schedule?

☐ Yes ☐ No

Work Location: In person

📌 Clinical Research Nurse / Clinical Research Coordinator (RN) (North York)
🏢 Dermatology Clinic
📍 North York