KisoJi Biotech is advancing next-generation antibody therapeutics through the integration of proprietary transgenic heavy chain-only antibody (HCAb) platforms, AI-guided discovery, functional screening technologies, and high-throughput single-cell screening systems.We are currently seeking a highly motivated Scientist – Immunology & Functional Assay Development to join our Assay Development (AD) team and support the advancement of immuno-oncology projects.This role will focus on the design, optimization, and execution of complex immune-cell functional assays to evaluate antibody therapeutic candidates and mechanisms of action. The successful candidate will contribute scientifically and technically to the development of translational in vitro assays that support discovery-stage decision‑making and candidate selection.This is a hands‑on laboratory position requiring robust expertise in immunology, immune cell biology, and functional assay development within a fast‑paced biotech environment.PositionSenior Research AssociateDepartmentAssay DevelopmentResponsibilitiesThe Scientist position entails working independently and collaboratively under the direction of the department head to:Design, develop, optimize, and execute immune cell‑based functional assays supporting antibody therapeutic discovery programsLead assay development activities for immuno‑oncology programsDevelop and optimize assays including:Conditional T cell activation assaysT cell‑mediated cytotoxicity assaysADCP (Antibody‑Dependent Cellular Phagocytosis)Macrophage phagocytosis assaysCytotoxicity and immune effector function assaysReporter‑based functional assaysCo‑culture and tumor cell killing modelsWork with primary immune cells and immune cell lines including:T cellsTHP‑1 cellsMacrophagesNK cellsTumor cell linesSupport mechanism‑of‑action studies and translational characterization of antibody candidatesAnalyze, interpret, and present experimental data to cross‑functional project teamsTroubleshoot assays and improve workflow robustness, reproducibility, and throughputContribute scientifically to experimental strategy, assay design, and project planning discussionsMaintain accurate experimental documentation and contribute to SOP generation and laboratory best practicesCollaborate closely with teams across antibody discovery, molecular biology, protein sciences, in vivo pharmacology, and computational biologyStay current with emerging technologies and scientific literature relevant to immunology and therapeutic antibody developmentEssential QualificationsPh.D. in Immunology, Cell Biology, Molecular Biology, Biotechnology, or a related field with 2–5 years of industry experience, ORM.Sc. with 7+ years of relevant industry experienceStrong hands‑on experience developing and executing immune‑cell functional assaysExperience working with:Primary immune cellsT cell activation systemsFlow cytometryCytotoxicity assaysCell‑based functional assaysExperience in immuno‑oncology, antibody therapeutics, or immune effector mechanism characterizationStrong understanding of immune signaling pathways and immune cell biologyExperience with assay troubleshooting, optimization,



and data interpretationStrong analytical and problem‑solving skillsExcellent organizational skills and attention to detailAbility to independently manage multiple projects in a fast‑paced environmentStrong written and verbal communication skillsLegally authorized to work in CanadaAssetsThe following experience would be considered highly desirable:Experience with bispecific antibodies or T cell engager therapeuticsExperience with macrophage biology and phagocytosis assaysExperience with high‑throughput or automated assay systemsExperience with reporter gene assays (e.G. luciferase, NFAT, CRE systems)Experience with flow cytometry panel design and analysisExperience with imaging‑based functional assaysExperience with Fc‑effector function assaysWhat We OfferBenefits Package IncludesHealth and Dental Insurance PlansPaid Vacation and HolidaysIncentive Programs IncludeTraining & Development Programs / CoursesAnnual Performance Reviews with Yearly BonusesOpportunity to work with cutting‑edge antibody discovery technologiesExposure to advanced AI‑guided therapeutic discovery platformsThe salary range for this position is$95,000–120,000 CAD, depending on experience, scientific expertise, and qualifications. Compensation will take into account internal equity, relevant technical experience, and educational background.KisoJi Biotech is a collaborative and science‑driven organization where innovation, teamwork, and scientific rigor are highly valued. Together, we believe we can help shape the future of antibody therapeutics and contribute meaningfully to the development of transformative medicines.#J-18808-Ljbffr

📌 Scientist – Immunology & Functional Assay Development - C$95,000 - C$120,000 A Year (Winnipeg)
🏢 KisoJi Biotech
📍 Winnipeg