Chronological ageing is a biological process that results in accumulated cellular damage, ultimately driving the onset of metabolic disfunction. We aim to develop new therapeutic approaches to these ageing-associated diseases, by targeting metabolism in cancer stem cells (CSCs) and senescent fibroblasts. More specifically, we will screen a series of chemical libraries containing FDA-approved drugs, natural products, and novel chemical entities, to identify compounds that can effectively age-associated metabolic features. Through this screening and validation approach, we will identify compounds that preferentially kill CSCs and senescent fibroblasts, using established cell lines.

This position will involve the screening and discovery of drugs that target the metabolic phenotype of senescent cells and cancer stem cells, across multiple cancer types.

Job Description
The purpose of this role is to support Lunella Biotech's mission in the discovery of anti-ageing and anti-cancer therapeutics. In more detail, you will work as part of a team of scientists, and will be responsible for the co-planning and execution of many experimental aspects of the project. This position will involve the identification and phenotypic validation of drugs that target senescent cells and cancer stem cells. The project will require the use of immunohistochemistry, immunocytochemistry and flow cytometry applied to relevant samples.

Responsibilities

To perform experiments in the laboratory to test hypotheses regarding ageing and cancer

To plan and execute the experiments related to the phenotypic validation of identified drugs targeting CSCs and senescent cells.





To apply complex research techniques for the phenotypic validation of drug hits using immunohistochemistry, immunofluorescence and flow cytometry of relevant samples.

Take overall responsibility for several experimental components of the project.

To maintain accurate records of data and analysis performed of specific experiments for a given project, conducts literature searches, and maintains an up-to-date knowledge of all current experimental methods through skilled reading.

To demonstrate a willingness to adapt and develop new skills.

To write up draft reports for manuscript publication and patent evaluation

To present data as required, during lab meetings and conferences

To collaborate with members within and outside of the laboratory

To comply with Health and Safety regulations

To promote equality and diversity and sustain an inclusive and supportive work environment

This role detail is a guide to the work you will initially be required to undertake. It may be changed from time to time to meet changing circumstances

Qualifications
Education

Completed Master's or PhD in related biological/pharmaceutical sciences

Publication record in peer-reviewed journals

Background & Experience
Essential criteria

Experience in flow cytometry/FACS analysis





Considerable experience of cell culture techniques

Experience in fluorescent microscopy

Experience in drug screening

Experience and a track record in working with and developing a variety of techniques

Experience in recording, analyzing and interpreting data

Desirable criteria

Experience in assays measuring metabolic parameters of cellular models

Experience in the co-culture of multiple cell types

Experience in proteomics

Experience in the generation of stable cell lines using transfection methods

Skills & Competencies

Proven ability to maintain high experimental reproducibility and reliability to ensure consistent and valid results

Ability to work independently within an agreed framework

Excellent communication skills on paper and verbally, including good IT skills

Ability to work as part of a team

Proven ability to follow directions

Ability and willingness to learn new analytical methods and skills

Good organizational skills

Additional Information
As an equal opportunity employer, Lunella Biotech Inc. is committed to achieving a skilled and diversified workforce that reflects the diversity of the Canadian population. We encourage applications from women, visible minorities, people with disabilities and Aboriginal people.

Additional Information
As an equal prospect employer, Lunella Biotech Inc. is committed to achieving a skilled and diversified workforce that reflects the diversity of the Canadian population. We encourage applications from women, visible minorities, people with disabilities and Aboriginal people.

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