KisoJi Biotech is advancing next-generation antibody therapeutics through the integration of proprietary transgenic heavy chain-only antibody (HCAb) platforms, AI-guided discovery, functional screening technologies, and high-throughput single-cell screening systems.We are currently expanding our antibody discovery capabilities and are seeking two Senior Research Associates to lead and support our single B cell screening and functional antibody discovery workflows using advanced technologies including the CellCelector platform and potentially droplet microfluidics-based screening systems.This is a highly hands-on laboratory role focused on screening plasma B cells following immunization campaigns to identify antibodies with desirable binding and/or functional activity. The position will involve close collaboration with multidisciplinary teams spanning molecular biology, protein engineering, AI-guided discovery, and functional assay development.The successful candidates will thrive in a fast-paced biotech environment, demonstrate robust experimental rigor, work independently, and contribute scientifically to the development of next-generation antibody discovery technologies.PositionSenior Research AssociateDepartmentAssay DevelopmentResponsibilitiesPlan and execute single B cell and plasma cell screening workflows following animal immunization campaignsOperate and optimize the CellCelector platform for single-cell isolation, imaging, clone recovery, and antibody discovery applicationsDevelop and execute screening assays for:Cell-based functional activitySupport the implementation and optimization of droplet microfluidics-based screening technologies for high-throughput functional antibody discoveryPerform mammalian cell culture and support functional screening workflows using reporter assays, flow cytometry, imaging systems, and cell-based assaysTroubleshoot methods, improve workflows, and contribute to the development of new antibody discovery technologiesMaintain accurate experimental records and clearly communicate results through reports, presentations,



and team discussionsAssist in SOP development, workflow standardization, and laboratory organizationCollaborate closely with multidisciplinary teams across discovery, assay development, computational biology, and protein engineeringParticipate in project planning, prioritization, and technology evaluation discussionsEssential QualificationsM.Sc. in Immunology, Cell Biology, Molecular Biology, Biotechnology, Bioengineering, or a related field with at least 5–7 years of industry experienceMinimum 3 years of hands-on experience in antibody discovery or single-cell screening workflowsExperience with mammalian cell culture and cell-based functional assaysExperience operating advanced screening or cell handling instrumentation such as:CellCelectorFACS / flow cytometry systemsExperience with one or more of the following:Single B cell screeningFunctional antibody screeningReporter-based functional assaysStrong troubleshooting and problem-solving skills with the ability to independently optimize assays and workflowsExcellent organizational skills and attention to detailAbility to work independently while effectively collaborating within cross-functional teamsStrong verbal and written communication skillsLegally authorized to work in CanadaAssetsExperience with droplet microfluidics systems for single-cell or functional screeningExperience with flow cytometry assay development and cell sortingExperience with reporter assays, imaging-based screening, or phenotypic screeningFamiliarity with automation and high-throughput screening systemsExperience in oncology or GPCR-focused therapeutic discovery programsWhat We OfferBenefits Package IncludesHealth and Dental Insurance PlansPaid Vacation and HolidaysIncentive Programs IncludeTraining & Development Programs / CoursesAnnual Performance Reviews with Yearly BonusesOpportunity to work with cutting-edge antibody discovery technologiesExposure to advanced AI-guided therapeutic discovery platformsThe salary range for this position is $80,000–120,000 CAD, depending on experience, technical expertise, and qualifications. Compensation will take into

📌 Senior Research Associate – Single B Cell Screening & Functional Antibody Discovery (Toronto)
🏢 Kisoji Biotechnology
📍 Toronto