Site Activation Manager

ICON plc is a world-leading healthcare intelligence and clinical research organization. We’re proud to foster an inclusive environment driving innovation and excellence, and we welcome you to join us on our mission to shape the future of clinical development.

As a Manager, Study Start Up at ICON, you will lead and oversee the start-up activities for clinical trials, ensuring that all processes are completed efficiently and in compliance with regulatory requirements.

What You Will Do:

You will manage day-to-day site start-up and activation activities, supporting your team to deliver quality outcomes.

- Core Responsibilities
- Build solid working relationships with investigative sites and support a positive sponsor-site experience throughout start-up.
- Collect, review, QC, and file essential documents required for submission and activation.
- Review and negotiate ICF changes with sites and stakeholders; manage translations, checklists, filing, and amendment updates as required.
- Ensure REB submissions are made and approval documentation is complete and activation-ready.
- Support Health Canada-related follow-up steps, including NOL and CTSI workflow coordination.
- Collaborate with sites and internal stakeholders to set and achieve Regulatory Greenlight (RGL) goals that support timely site activation.
- Escalate risks, manage timelines, and maintain accurate documentation and tracking in systems such as CTMS and the eTMF.

Your Profile:

You will have solid site start-up and activation experience, with the ability to manage competing priorities.

Required qualifications and experience

- Bachelor's degree in a relevant scientific discipline or healthcare-related field
- Clinical trial start-up experience in a site-facing or dedicated site role.
- Solid understanding of ICH GCP, TCPS-2, Quebec/provincial REB requirements, and the Health Canada submissions process.
- Fluency in English and French Canadian.
- Experience with essential document collection, QC, and filing.
- Experience with ICF review, negotiation,



and amendment management.
- Experience with Canadian REB submissions and approval workflows, including Health Canada coordination steps.
- Strong cross-functional collaboration and stakeholder management skills within a sponsor-partner operating model involving ICON.

What ICON can offer you:

Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include

- Various annual leave entitlements
- A range of health insurance offerings to suit you and your family’s needs.
- Competitive retirement planning offerings to maximize savings and plan with confidence for the years ahead.
- Global Employee Assistance Programme, LifeWorks, offering 24-hour access to a global network of over 80,000 independent specialized professionals who are there to support you and your family’s well-being.
- Life assurance
- Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidized travel passes, health assessments, among others.

Visit our careers site to read more about the benefits ICON offers.

At ICON, inclusion & belonging are fundamental to our culture and values. We’re dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know or submit a request here

📌 Site Activation Manager- French Speaking (Montreal)
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📍 Montreal