We are seeking a motivated Postdoctoral Fellow to step into a scientific leadership role on a CIHR-funded project . This study explores a preclinical model of primary progressive MS based on an Nr1h3 (LXRA) mutation found in families with a highly severe and aggressive form of the disease, which disrupts immunomodulatory pathways and cholesterol reverse transport/lipid metabolism.

As part of this vibrant ecosystem, you will have access to numerous opportunities for both foundational and professional development, including high-profile seminar series, career workshops, and multidisciplinary networking events.

Core Responsibilities

· Drive the Science: Lead aspects of the CIHR-funded project investigating mechanisms of neuroinflammation, myelin injury, and repair.

· Execute In Vivo & In Vitro Models: Design and run studies using transgenic mouse models, macrophages, microglia, and CNS-resident immune cells.

· Oversee Cell Culture Studies: Isolate and maintain primary rodent neural (neuronal, glial) and immune cell cultures alongside cell lines.

· Utilize Advanced Techniques: Perform phagocytosis assays, IHC, multicolor spectral flow cytometry, advanced microscopic analyses, live-cell imaging, and molecular analyses (qPCR, siRNA, cDNA delivery).

· Integrate Omics Approaches: Oversee and interpret bulk/single-cell transcriptomic and proteomic data.

· Communicate & Publish: Synthesize complex datasets, author manuscripts, contribute to grants, and present findings at international conferences.

· Mentor & Collaborate:



Provide hands-on mentorship to graduate and undergraduate students while collaborating with academic, clinical, and interdisciplinary team partners.

Qualifications

· Education: PhD in neuroscience, immunology, pathology, cell biology, or a related biomedical science field.

· Technical Strengths: Strong hands-on experience with mouse models of demyelinating disease, cell culture methods (primary rodent neural/immune cells), multicolor spectral flow, advanced microscopic analyses, or live-cell imaging.

· Data Expertise: Familiarity or direct experience with single-cell transcriptomics, proteomics, or systems biology datasets.

· Leadership Traits: Proven record of peer-reviewed publications, scientific independence, creativity, and strong organizational skills.

· Team Mindset: Dedicated to scientific rigor, reproducibility, inclusive mentorship, and working across diverse perspectives.

How to Apply

Candidates can review formal requirements and apply directly through the UBC Faculty Careers Portal (Job ID: JR25808-1) .

For informal inquiries, please email your application package directly to Dr. Jacqueline Quandt at [email protected] with the subject line "PDF in Neuroinflammation" . Your submission should include a statement of research interests, a detailed CV specifying your publication contributions, and contact information for 3 qualified references.

- Review of applications begins immediately on a rolling basis.

📌 Postdoctoral Research Fellow - Neuroinflammation & Neuroimmunology (Vancouver)
🏢 The University of British Columbia
📍 Vancouver