UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care.

UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.

New or Replacement Position : New Site : Princess Margaret Cancer Centre Department : Research Salary Range : $31.03 - $46.84 hourly Shifts : Monday - Friday Temporary Full-Time (1 year contract) Our lab is a multidisciplinary research program based at the Princess Margaret Cancer Centre, University Health Network, and closely integrated with the Structural Genomics Consortium. We operate at the intersection of clinical oncology, experimental biology, and functional genomics, with a focus on understanding chromatin architecture, epigenetic regulation, and tumor heterogeneity in cancer. The lab uses 3D genome mapping, chromatin profiling, next-generation sequencing, patient-derived models, and multi-omic approaches to identify regulatory mechanisms that may inform precision oncology strategies, biomarker discovery, and epigenome-informed therapeutic approaches.





We are seeking a highly motivated Research Technician with strong wet-lab experience to support and execute experimental projects in cancer epigenomics and 3D genome biology. The successful candidate will contribute to projects involving chromatin conformation assays, functional epigenomics, next-generation sequencing library preparation, and patient-derived model systems. This position is ideal for a candidate with hands‑on experience in molecular biology, genomics, epigenomics, and cancer biology who is interested in working in a collaborative, translational research environment.

Perform and optimize molecular biology and functional genomics experiments related to cancer epigenomics. Prepare next‑generation sequencing libraries across multiple assay types. Support sample processing, quality control, library preparation, and coordination of sequencing submissions.

Maintain accurate experimental records, protocols, sample inventories, and laboratory documentation. Assist with troubleshooting and optimization of complex wet‑lab protocols. Coordinate with computational scientists and other team members to support data generation, interpretation, and project progress.

Assist with ordering, reagent preparation, equipment maintenance, and general laboratory organization. Support training of junior lab members or students in established protocols, as appropriate. Contribute to a collaborative, rigorous, and well‑organized lab environment.

At minimum,



Bachelor'sdegree in Molecular Biology, Cancer Biology, Genetics, Genomics, Biochemistry, Cell Biology, or a related field required Master's degree an asset Minimum of 3 years of relevant wet‑lab research experience required Solid hands‑on experience with molecular biology and genomics techniques.

Experience with next‑generation sequencing library preparation. Excellent communication skills and fluency in English, written and spoken. Ability to work effectively in a collaborative, multidisciplinary research environment.

Direct experience with 3D genome assays, such as Hi‑C, HiChIP, Capture‑C, Micro‑C, or related methods an asset Experience with single‑cell or spatial genomics workflows an asset Experience with low‑input or challenging clinical/research samples an asset Basic familiarity with genomic data analysis concepts and tools, including R, Python, command‑line environments, or sequencing QC metrics an asset Experience working in a translational cancer research environment an asset Prior experience contributing to manuscripts, reports, or grant‑related experimental summaries an asset Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP A flexible work environment Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on‑site gyms, etc.) UHN may use artificial intelligence technologies to assist in the screening, assessment, and selection of candidates for this position. Please be advised that a Criminal Record Check may be required of the successful candidate. Requests for accommodation can be made at any stage of the recruitment process.

📌 Research Technician -Temporary Full-Time (Toronto)
🏢 University Health Network
📍 Toronto