Scientifique principal(e) - Innocuité non clinique at AbCellera
About the role AbCellera is dedicated to overcoming challenges to provide innovative medications to those in need. We seek a strategic and experienced principal scientist to join our expanding non-clinical safety team in Vancouver, Canada. In this role, you will design, plan, and oversee toxicological studies, ensuring compliance with regulatory standards while supporting early and late-stage programs.
Key facts Location: Vancouver, Canada Engagement: Full-time Team: Non-clinical safety
What you'll do Lead the planning, design, implementation, and interpretation of non-clinical toxicology programs to support research new drug applications, clinical trials, and biological product approvals, including general toxicity and reproductive and developmental toxicology studies.
Serve as the primary scientific liaison with contract research organizations, providing strategic oversight during protocol development, study execution, data interpretation, and report finalization to ensure high-quality non-clinical studies are completed on time and in compliance with good laboratory practices.
Act as a key member of cross-functional discovery and development program teams, offering toxicology expertise to guide candidate selection, risk assessment, and overall program advancement.
Conduct critical scientific evaluations of toxicological data and communicate clear, actionable assessments and recommendations regarding risk-benefit profiles to project teams and senior management, including implications for clinical development and regulatory strategy.
Write and review non-clinical safety sections of regulatory documents (research new drug applications, clinical trial applications, investigator brochures, and biological product submissions) and participate as a subject matter expert in international regulatory discussions and responses to health authorities.




Drive the development and evolution of integrated non-clinical safety strategies across AbCellera's product portfolio, ensuring consistency, scientific rigor, and alignment with corporate objectives.
Maintain scientific leadership by staying informed on advancements in toxicology, new methodologies, and evolving regulatory guidelines, proactively translating this knowledge into best practices for internal programs.
Requirements Extensive expertise in non-clinical toxicology in compliance with good laboratory practices, including hands-on experience with FDA Title 21 Part 58, and a solid understanding of non-clinical regulatory guidelines from the FDA, ICH, and EMA.
Proven ability to design, supervise, and interpret toxicological studies in research and development programs, with strong preference for experience in oncology and/or antibody-drug conjugate programs.
A Ph.D. in toxicology or a related field, with a minimum of 8 years of relevant experience in biological product development; candidates with a Master's degree and at least 12 years of directly applicable experience will also be considered.
Strong communication skills to facilitate scientific discussions and influence decision-making within complex, cross-functional matrix teams.
Excellent scientific writing abilities with experience in drafting and reviewing toxicology reports and regulatory documents.
Strong organizational skills and the ability to prioritize effectively, managing multiple programs and timelines in a fast-paced environment.
Rigorous scientific judgment and critical thinking for problem-solving, enabling the analysis of complex data, risk identification, and strategic solution proposals.
Ability to thrive in a dynamic,



ever-changing environment, demonstrating flexibility, resilience, and a proactive approach to change.
DABT accreditation is highly desirable but not mandatory.
What we offer In addition to a competitive base salary, we provide stock options, an annual performance-based bonus, and a 6% contribution to a retirement savings plan without employee matching. You will also receive an annual allowance of CAD 1,500 for an active lifestyle, vacation time, flexible scheduling options, professional development opportunities, and comprehensive health benefits.
Scientific and technical mentoring is a priority at AbCellera. Our community spirit and strong connections among team members are fostered through various initiatives, clubs, and social activities.
The organization Developing medications is the most important task there is. AbCellera is a clinical-stage biotechnology company focused on discovering and developing antibody-based therapies in endocrinology, women's health, immunology, and oncology. We have established a platform to advance antibody drug development programs from target identification to clinical phases, and we utilize this platform to expand our internal product portfolio. Currently, our pipeline includes two candidates in clinical development, two candidates in preclinical development preparing for investigational current drug applications, and over 20 active research programs covering various therapeutic modalities and indications. We believe that determined individuals can truly make a positive impact when they share a common vision and work together. That is why personality and intelligence are central to our hiring process, beyond just resumes and experience. We seek dynamic and energetic individuals who want to feel their days are spent meaningfully and that their work truly matters. Ultimately, our success is defined by the benefits our medications bring to patients.

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📌 Scientifique principal(e) — Innocuité non clinique (British Columbia)
🏢 AbCellera
📍 British Columbia