Apply on Kit Job: kitjob.ca/job/2eue13

Chief Scientific Officer — Personalized Cancer Vaccines

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Helixion Therapeutics | Vancouver, BC (Remote considered)

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Helixion Therapeutics is building Elyra — an AI-driven neoantigen discovery engine that converts tumor DNA into ranked neoantigen candidates for personalized mRNA cancer vaccines. DNA in. Vaccine blueprint out. In days.

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Our production scorer has been externally validated on the TESLA benchmark (AUC 0.812, outperforming pVACtools), and we're preparing for our first clinical partnerships. We're looking for a Chief Scientific Officer to lead our scientific strategy from computational validation through IND-stage regulatory milestones.

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What you'll own

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The entire scientific trajectory of a personalized cancer vaccine company at its most formative stage. You'll shape the R&D; roadmap, guide neoantigen scoring model development, design clinical validation studies, build relationships with academic and pharma partners, and lead our regulatory strategy toward first-in-human applications. This is a co-founder-level role with meaningful equity.

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What we're looking for

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A scientist with deep expertise in neoantigen biology and cancer immunology who can bridge computational prediction with clinical translation. Specifically:

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- PhD in immunology, oncology, computational biology, or a related field




- Published research in neoantigen discovery, neoantigen vaccines, or personalized cancer immunotherapy
- Experience with IND-stage regulatory processes or clinical trial design for cancer vaccines
- Familiarity with MHC binding prediction, immunogenicity scoring, or related computational tools (pVACseq, MHCflurry, NetMHCpan)
- Ability to evaluate and improve ML-based scoring models for neoantigen prioritization

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- Experience with mRNA vaccine platforms
- Track record of translating computational or preclinical work into clinical programs
- Existing relationships with oncology KOLs, clinical sites, or pharma partners
- Regulatory experience with FDA or Health Canada

About Helixion:n

Founded by Sean Clark (CEO of Hut 8 Mining, TSX-listed; founder of First Block Capital) and Marc van der Chijs (co-founder of Tudou.com, NASDAQ-listed, sold to Alibaba). We're pre-seed, preparing for a TSXV/CSE listing, and believe cancer vaccine design is fundamentally a software problem — rapid, reproducible, scalable, affordable.

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Headquartered in Vancouver, BC. Competitive salary, significant equity, and the chance to shape a company from the ground up.

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To apply: Message Sean Clark directly on LinkedIn or email [email protected].

Apply on Kit Job: kitjob.ca/job/2eue13

📌 Chief Scientific Officer (Vancouver)
🏢 Helixion Therapeutics
📍 Vancouver